Abstract
Antiepileptic drugs have been valuable therapeutic tools, but may have adverse effects. Their effects, whether therapeutic or adverse, may vary among subjects and can be age-specific. In this article, we focus on the GABA A signaling cascades and review the known age-related changes in its effects. The finding of sex-specific patterns in the ontogeny of GABA A signaling has enabled us to reveal factors, such as seizures and stress that modulate the biological age of the system. To cure epilepsy without side effects, it is important to implement therapies appropriate for the developmental stage of the targeted systems.
Original language | English (US) |
---|---|
Title of host publication | Encyclopedia of Basic Epilepsy Research |
Publisher | Elsevier |
Pages | 1025-1033 |
Number of pages | 9 |
ISBN (Electronic) | 9780123739612 |
DOIs | |
State | Published - Jan 1 2009 |
Keywords
- Age
- Antiepileptic
- Chloride cotransporter
- Development
- GABA
- GABA receptor
- Hippocampus
- Seizure
- Sex
- Substantia nigra
ASJC Scopus subject areas
- General Medicine
- General Neuroscience