Pediatric Epilepsy: Age-Specific Responses to Antiepileptic Drugs

A. S. Galanopoulou; S. L. Moshé

doi:10.1016/B978-012373961-2.00261-7

Pediatric Epilepsy: Age-Specific Responses to Antiepileptic Drugs

A. S. Galanopoulou, S. L. Moshé

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Antiepileptic drugs have been valuable therapeutic tools, but may have adverse effects. Their effects, whether therapeutic or adverse, may vary among subjects and can be age-specific. In this article, we focus on the GABA_A signaling cascades and review the known age-related changes in its effects. The finding of sex-specific patterns in the ontogeny of GABA_A signaling has enabled us to reveal factors, such as seizures and stress that modulate the biological age of the system. To cure epilepsy without side effects, it is important to implement therapies appropriate for the developmental stage of the targeted systems.

Original language	English (US)
Title of host publication	Encyclopedia of Basic Epilepsy Research
Publisher	Elsevier Inc.
Pages	1025-1033
Number of pages	9
ISBN (Print)	9780123739612
DOIs	https://doi.org/10.1016/B978-012373961-2.00261-7
State	Published - Jan 1 2009

Keywords

Age
Antiepileptic
Chloride cotransporter
Development
GABA
GABA receptor
Hippocampus
Seizure
Sex
Substantia nigra

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

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10.1016/B978-012373961-2.00261-7

Cite this

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abstract = "Antiepileptic drugs have been valuable therapeutic tools, but may have adverse effects. Their effects, whether therapeutic or adverse, may vary among subjects and can be age-specific. In this article, we focus on the GABAA signaling cascades and review the known age-related changes in its effects. The finding of sex-specific patterns in the ontogeny of GABAA signaling has enabled us to reveal factors, such as seizures and stress that modulate the biological age of the system. To cure epilepsy without side effects, it is important to implement therapies appropriate for the developmental stage of the targeted systems.",

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AU - Moshé, S. L.

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KW - Chloride cotransporter

KW - Development

KW - GABA

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KW - Hippocampus

KW - Seizure

KW - Sex

KW - Substantia nigra

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ER -

Pediatric Epilepsy: Age-Specific Responses to Antiepileptic Drugs

Abstract

Keywords

ASJC Scopus subject areas

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