@article{a1743e589c6a437ea660ef2e74ae85d9,
title = "Peaceful use of disastrous neurotoxicants",
abstract = "The increasing exposure to environmental neurotoxicants in the last decades caused serious health problems in the world population. Some of the neurotoxic agents are being used in agriculture and household such as insecticides and rodenticides and others are of natural origin like snake and scorpion venoms. Additional group of harmful substances is the chemical warfare agents including nerve and blistering agents that are known for their disastrous effects on neuronal tissues. The present paper presents a combination of epidemiological/clinical and molecular approaches for investigating the effect of certain groups of neurotoxicants on a variety of pathologies. The work of Finkelstein and coworkers describes epidemiological and clinical studies on acute and chronic organophosphate (OP)-induced neurotoxicity in certain populations in Israel. They mainly investigated the neurotoxic effects of low-level long-term exposure to OP in agricultural areas but also dealt with acute exposures as well. A molecular approach to OP mechanism of neuronal injury was described by Milatovic and coworkers. They demonstrated OP-induced oxidative injury in pyramidal neurons in the CA1 hippocampal area and its suppression by antioxidants. Lecht and coworkers described the novel snake venom angioneurins as important mediators of the physiological cross-talk between the cardiovascular and nervous systems. They also showed that under certain conditions these angioneurins may induce pathologies such as tumor development or disruption of the vascular barrier function during envenomation. Additional mechanistic/therapeutic approach was presented by Brodsky, Rosengarten, Proscura, Shapira and Wormser. They developed a novel anti-inflammatory peptide that reduced skin irritation induced by heat and sulfur mustard (SM) stimuli. Since SM causes neuropsychiatric symptoms and alterations in neurological functions this peptide may serve as a potential treatment of neuronal injuries caused by environmental neurotoxicants. These reviews highlight different aspects of neurotoxicity, addressing epidemiology and mechanisms of toxicity; and identifying novel potential therapies.",
keywords = "Angioneurins, Anti-inflammatory peptide III, Anti-inflammatory peptide IIIM1, Anti-inflammatory peptides, Children, Diisopropylphosphorofluoridate, Experimental autoimmune encephalitis, Exposure, NGF, Neurobehavioral effects, Neurodegeneration, Neurotoxicity, Organophosphates, Oxidative stress, Pesticides, Povidone-iodine, Skin irritants, Snake venom, VEGF, Vipera palestinae",
author = "Yoram Finkelstein and Dejan Milatovic and Philip Lazarovici and Amit Ophir and Richter, {Elihu D.} and Michael Aschner and Shimon Lecht and Cezary Marcinkiewicz and Lelkes, {Peter I.} and Snjezana Zaja-Milatovic and Gupta, {Ramesh C.} and Berta Brodsky and Avigail Rosengarten and Elena Proscura and Elena Shapira and Uri Wormser",
note = "Funding Information: The authors{\textquoteright} work was supported by National Institute of Health grants NS057223 (DM) and NIEHS07331 (MA). Snake venom angioneurins: toxic or therapeutic growth factors? &z.star; Shimon Lecht 1 , Cezary Marcinkiewicz 2 , Peter I. Lelkes 3 , Philip Lazarovici 1 1 Laboratory of Neuropharmacology, Neuro-oncology and Neural Engineering, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel 2 Department of Biology, Temple University, Philadelphia, PA 19122, USA 3 Laboratory of Cellular Tissue Engineering, School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA &z.star; This study is part of the PhD thesis of SL to be submitted to The Hebrew University of Jerusalem. Vipera palestinae venom toxicity Funding Information: The present study was supported by the USAMRMC Cooperative Agreements DAMD17-98-2-8009 and DAMD17-03-2-0013, the Binational Science Foundation Research Project 2001186 and the Israel Science Foundation (Grant No. 747/05). Funding Information: We would like to acknowledge the grant-in-aid from the Stein Family Foundations (PL and PIL), Israeli Science Foundation (PL) and NIH (CM); PL is affiliated and partially supported by the David R. Bloom Center for Pharmacy; and the Dr. Adolf and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at The Hebrew University of Jerusalem, Israel; SL is supported by “Eshkol” fellowship from the Israeli Ministry of Science and Technology. From skin irritants to anti-inflammatory peptides Berta Brodsky, Avigail Rosengarten, Elena Proscura, Elena Shapira, Uri Wormser 1 Institute of Drug Research, School of pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, 91120 Jerusalem, Israel 1 Is affiliated with David R. Bloom Center for Pharmacy at the Hebrew University and The Dr. Adolf and Klara Brettler Centre for Research in Molecular Pharmacology and Therapeutics at the Hebrew University. Introduction Funding Information: The authors are indebted to Mrs. Alycia Buford-Penn and Mrs. Nathanela Kaplan for their technical assistance. Yoram Finkelstein was partially supported by grants from Environment and Health Fund (EHF) – No. RGA0903; Chief Scientist, Israel Ministry of Environmental Protection – No. 7-2-1; and Chief Scientist, Israel Ministry of Industry, Trade and Labor grant – No. 36-13-13-01. Michael Aschner was partially supported by grants from the National Institute of Environmental Health Science (NIEHS) grants 07331, 10563 and Department of Defense (DoD) W81XWH-05-1-0239. Suppression of oxidative injury and neurodegeneration in cholinergic toxicity Dejan Milatovic 1 , Snjezana Zaja-Milatovic 1 , Ramesh C. Gupta 2 , Michael Aschner 1 1 Vanderbilt University School of Medicine, Department of Pediatrics/Pediatric Toxicology, Nashville, TN, USA 2 Murray State University, Breathitt Veterinary Center, Hopkinsville, KY, USA Introduction ",
year = "2010",
month = sep,
doi = "10.1016/j.neuro.2010.06.009",
language = "English (US)",
volume = "31",
pages = "608--620",
journal = "Neurotoxicology",
issn = "0161-813X",
publisher = "Elsevier",
number = "5",
}