Pathophysiology of Obstructive Sleep Apnea Syndrome in Childhood

Raanan Arens; Sanghun Sin; David M. Wootton

doi:10.1007/978-3-030-65574-7_35

Pathophysiology of Obstructive Sleep Apnea Syndrome in Childhood

Raanan Arens
, Sanghun Sin
, David M. Wootton

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Obstructive sleep apnea syndrome (OSAS) occurs in subjects of all ages, from the premature infant to through adulthood. Much remains unknown about the pathophysiology of the syndrome. However, research suggests that OSAS in all age groups is due to a combination of both anatomic airway narrowing and abnormal upper airway neuromotor tone impacting the biomechanical properties of the airway in sleep. This chapter discusses the pathophysiologic aspects of this syndrome across childhood.

Original language	English (US)
Title of host publication	Pediatric Sleep Medicine
Subtitle of host publication	Mechanisms and Comprehensive Guide to Clinical Evaluation and Management
Publisher	Springer Science+Business Media
Pages	437-457
Number of pages	21
ISBN (Electronic)	9783030655747
ISBN (Print)	9783030655730
DOIs	https://doi.org/10.1007/978-3-030-65574-7_35
State	Published - Jan 1 2021

Keywords

Airway dynamics
Airway mechanics
Airway morphology
Computational fluid dynamics (CFD)
Critical closing pressure (Pcrit)
Genetics
Magnetic resonance imaging (MRI)
Neuromotor tone
Obstructive sleep apnea syndrome (OSAS)
Resistive loading
Ventilatory control

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1007/978-3-030-65574-7_35

Cite this

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title = "Pathophysiology of Obstructive Sleep Apnea Syndrome in Childhood",

abstract = "Obstructive sleep apnea syndrome (OSAS) occurs in subjects of all ages, from the premature infant to through adulthood. Much remains unknown about the pathophysiology of the syndrome. However, research suggests that OSAS in all age groups is due to a combination of both anatomic airway narrowing and abnormal upper airway neuromotor tone impacting the biomechanical properties of the airway in sleep. This chapter discusses the pathophysiologic aspects of this syndrome across childhood.",

keywords = "Airway dynamics, Airway mechanics, Airway morphology, Computational fluid dynamics (CFD), Critical closing pressure (Pcrit), Genetics, Magnetic resonance imaging (MRI), Neuromotor tone, Obstructive sleep apnea syndrome (OSAS), Resistive loading, Ventilatory control",

author = "Raanan Arens and Sanghun Sin and Wootton, \{David M.\}",

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AU - Sin, Sanghun

AU - Wootton, David M.

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PY - 2021/1/1

Y1 - 2021/1/1

N2 - Obstructive sleep apnea syndrome (OSAS) occurs in subjects of all ages, from the premature infant to through adulthood. Much remains unknown about the pathophysiology of the syndrome. However, research suggests that OSAS in all age groups is due to a combination of both anatomic airway narrowing and abnormal upper airway neuromotor tone impacting the biomechanical properties of the airway in sleep. This chapter discusses the pathophysiologic aspects of this syndrome across childhood.

AB - Obstructive sleep apnea syndrome (OSAS) occurs in subjects of all ages, from the premature infant to through adulthood. Much remains unknown about the pathophysiology of the syndrome. However, research suggests that OSAS in all age groups is due to a combination of both anatomic airway narrowing and abnormal upper airway neuromotor tone impacting the biomechanical properties of the airway in sleep. This chapter discusses the pathophysiologic aspects of this syndrome across childhood.

KW - Airway dynamics

KW - Airway mechanics

KW - Airway morphology

KW - Computational fluid dynamics (CFD)

KW - Critical closing pressure (Pcrit)

KW - Genetics

KW - Magnetic resonance imaging (MRI)

KW - Neuromotor tone

KW - Obstructive sleep apnea syndrome (OSAS)

KW - Resistive loading

KW - Ventilatory control

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DO - 10.1007/978-3-030-65574-7_35

M3 - Chapter

AN - SCOPUS:105013374123

SN - 9783030655730

SP - 437

EP - 457

BT - Pediatric Sleep Medicine

PB - Springer Science+Business Media

ER -

Pathophysiology of Obstructive Sleep Apnea Syndrome in Childhood

Abstract

Keywords

ASJC Scopus subject areas

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