Pathophysiological insights into the cardiomyopathy of chagas' disease

Stephen A. Morris, Herbert B. Tanowitz, Murray Wittner, John P. Bilezikian

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, thge ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.

Original languageEnglish (US)
Pages (from-to)1900-1909
Number of pages10
Issue number6
StatePublished - 1990


  • Cardiomyopathy
  • Chagas' disease
  • Microcirculation
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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