Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia

D. R. Dufour, S. J. Marx, A. M. Spiegel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Occasionally, patients with other causes of hypercalcemia undergo parathyroidectomy for suspected primary hyperparathyroidism. We studied the parathyroid glands from 12 persons with nonparathyroid hypercalcemia. Glands from these individuals were similar to normal glands in size and fat:parenchymal ratio, showing neither atrophy nor hyperplasia. A distinctive histologic feature, also seen in hyperparathyroid hypercalcemia, is the presence of pale, vacuolated cells arranged in a trabecular pattern. Recognition of normal parathyroid parenchymal weight and the nonspecific nature of these vacuolated cells is necessary to prevent false-positive diagnoses of parathyroid hyperplasia. For glands which have not been weighed, parenchymal cross-sectional area can only be used as a rough index of parenchymal weight.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalAmerican Journal of Surgical Pathology
Issue number1
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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