Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart; G. J. de Vos; G. J. te Meerman; A. G. Uitterlinden; J. Vijg

doi:10.1038/365469a0

Parallel genome analysis by two-dimensional DNA typing.

E. Mullaart
, G. J. de Vos
, G. J. te Meerman
, A. G. Uitterlinden
, J. Vijg

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

Original language	English (US)
Pages (from-to)	469-471
Number of pages	3
Journal	Nature
Volume	365
Issue number	6445
DOIs	https://doi.org/10.1038/365469a0
State	Published - Sep 30 1993
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/365469a0

Cite this

@article{a51990a9c1bd4beb910e54bfd809955e,

title = "Parallel genome analysis by two-dimensional DNA typing.",

abstract = "By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.",

author = "E. Mullaart and \{de Vos\}, \{G. J.\} and \{te Meerman\}, \{G. J.\} and Uitterlinden, \{A. G.\} and J. Vijg",

year = "1993",

month = sep,

day = "30",

doi = "10.1038/365469a0",

language = "English (US)",

volume = "365",

pages = "469--471",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6445",

}

TY - JOUR

T1 - Parallel genome analysis by two-dimensional DNA typing.

AU - Mullaart, E.

AU - de Vos, G. J.

AU - te Meerman, G. J.

AU - Uitterlinden, A. G.

AU - Vijg, J.

PY - 1993/9/30

Y1 - 1993/9/30

N2 - By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

AB - By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

UR - https://www.scopus.com/pages/publications/0027926585

UR - https://www.scopus.com/pages/publications/0027926585#tab=citedBy

U2 - 10.1038/365469a0

DO - 10.1038/365469a0

M3 - Article

C2 - 8413593

AN - SCOPUS:0027926585

SN - 0028-0836

VL - 365

SP - 469

EP - 471

JO - Nature

JF - Nature

IS - 6445

ER -

Parallel genome analysis by two-dimensional DNA typing.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this