TY - JOUR
T1 - Pancreatic neuroendocrine paraneoplastic optic neuropathy
T2 - Confirmation with antibody to optic nerve and hepatic metastasis
AU - Slamovits, Thomas L.
AU - Posner, Jerome B.
AU - Reidy, Diane L.
AU - Thirkill, Charles E.
AU - Keltner, John L.
PY - 2013/3
Y1 - 2013/3
N2 - A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.
AB - A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.
UR - http://www.scopus.com/inward/record.url?scp=84874111397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874111397&partnerID=8YFLogxK
U2 - 10.1097/WNO.0b013e3182699b2a
DO - 10.1097/WNO.0b013e3182699b2a
M3 - Article
C2 - 22926698
AN - SCOPUS:84874111397
SN - 1070-8022
VL - 33
SP - 21
EP - 25
JO - Journal of Neuro-Ophthalmology
JF - Journal of Neuro-Ophthalmology
IS - 1
ER -
