Oxidative Stress and Notch Signaling: Implications in Cancer

Both Notch signaling and oxidative stress have pivotal roles in health and diseases. Emerging evidences indicate that they both can regulate each other to influence crucial processes necessary for the tumorigenesis. Notch signaling can modulate oxidative stress by directly regulating some of the critical components related to the generation of oxidative stress or indirectly by downregulating the antioxidant defense system. Meanwhile, oxidative stress can also regulate Notch signaling at various stages of tumor development. Therefore, understanding the complex interplay between the Notch signaling and oxidative stress in cancer may lead to the development of effective therapeutic strategies for the treatment of cancer. This chapter presents an overview of the Notch signaling and oxidative stress in cancer, how they interact and regulate each other, and what are the implications of this cross talk in cancer. Further, various anticancer therapeutics which target oxidative stress and Notch signaling in cancer are also discussed.