Oxidative stress and angiogenesis in tumor progression

Atilla Soran; Oya Andacoglu; Bennett Van Houten

doi:10.1201/b14907

Oxidative stress and angiogenesis in tumor progression

Atilla Soran, Oya Andacoglu, Bennett Van Houten

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

During tumor initiation, cells often become hypoxic and under these conditions, cancer cells activate signaling pathways, which regulate metabolism, proliferation, angiogenesis and death. This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression, and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of tumor.

Original language	English (US)
Title of host publication	Endothelium
Subtitle of host publication	Molecular Aspects of Metabolic Disorders
Publisher	CRC Press
Pages	394-425
Number of pages	32
ISBN (Electronic)	9781466582804
ISBN (Print)	9781466582798
DOIs	https://doi.org/10.1201/b14907
State	Published - Jan 1 2013
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1201/b14907

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title = "Oxidative stress and angiogenesis in tumor progression",

abstract = "During tumor initiation, cells often become hypoxic and under these conditions, cancer cells activate signaling pathways, which regulate metabolism, proliferation, angiogenesis and death. This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression, and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of tumor.",

author = "Atilla Soran and Oya Andacoglu and {Van Houten}, Bennett",

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doi = "10.1201/b14907",

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N2 - During tumor initiation, cells often become hypoxic and under these conditions, cancer cells activate signaling pathways, which regulate metabolism, proliferation, angiogenesis and death. This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression, and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of tumor.

AB - During tumor initiation, cells often become hypoxic and under these conditions, cancer cells activate signaling pathways, which regulate metabolism, proliferation, angiogenesis and death. This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression, and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of tumor.

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M3 - Chapter

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BT - Endothelium

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ER -

Oxidative stress and angiogenesis in tumor progression

Abstract

ASJC Scopus subject areas

UN SDGs

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