Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus

Shyam Prabhakaran, Matthew Bramlage, Mark A. Edgar, Betty Diamond, John A. Hardin, Bruce T. Volpe

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.

Original languageEnglish (US)
Pages (from-to)1843-1845
Number of pages3
JournalJournal of Rheumatology
Issue number9
StatePublished - Sep 2005


  • Autoantibodies
  • Immunology
  • Nervous system
  • Pathology
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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