Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells

Swati Haldar; Himanshu Agrawal; Sarama Saha; Alex R. Straughn; Partha Roy; Sham S. Kakar

doi:10.7150/ijbs.63721

Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells

Swati Haldar, Himanshu Agrawal, Sarama Saha, Alex R. Straughn, Partha Roy, Sham S. Kakar

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.

Original language	English (US)
Pages (from-to)	675-692
Number of pages	18
Journal	International Journal of Biological Sciences
Volume	18
Issue number	2
DOIs	https://doi.org/10.7150/ijbs.63721
State	Published - 2022
Externally published	Yes

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Applied Microbiology and Biotechnology
Molecular Biology
Developmental Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7150/ijbs.63721

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title = "Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells",

abstract = "Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.",

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AU - Haldar, Swati

AU - Agrawal, Himanshu

AU - Saha, Sarama

AU - Straughn, Alex R.

AU - Roy, Partha

AU - Kakar, Sham S.

N1 - Publisher Copyright: © The author(s).

PY - 2022

Y1 - 2022

N2 - Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.

AB - Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.

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M3 - Review article

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JO - International Journal of Biological Sciences

JF - International Journal of Biological Sciences

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Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells

Abstract

ASJC Scopus subject areas

UN SDGs

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