TY - JOUR
T1 - Out of the frying pan
T2 - Dietary saturated fat influences nonalcoholic fatty liver disease
AU - Parks, Elizabeth
AU - Yki-Järvinen, Hannele
AU - Hawkins, Meredith
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.
AB - Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.
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U2 - 10.1172/JCI92407
DO - 10.1172/JCI92407
M3 - Review article
C2 - 28112684
AN - SCOPUS:85014096599
SN - 0021-9738
VL - 127
SP - 454
EP - 456
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 2
ER -