Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

James Riddell; Andrew F. Brouwer; Heather M. Walline; Lora P. Campredon; Rafael Meza; Marisa C. Eisenberg; Emily C. Andrus; Rachel L. Delinger; Monica L. Yost; Jodi K. McCloskey; Trey B. Thomas; Suiyuan Huang; Robert L. Ferris; Dong Moon Shin; Carole Fakhry; Thomas Ow; Daniel Li; Ashley Berlot; Thomas E. Carey; Nicolas F. Schlecht

doi:10.1016/j.tvr.2022.200237

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

James Riddell, Andrew F. Brouwer, Heather M. Walline, Lora P. Campredon, Rafael Meza, Marisa C. Eisenberg, Emily C. Andrus, Rachel L. Delinger, Monica L. Yost, Jodi K. McCloskey, Trey B. Thomas, Suiyuan Huang, Robert L. Ferris, Dong Moon Shin, Carole Fakhry, Thomas Ow, Daniel Li, Ashley Berlot, Thomas E. Carey, Nicolas F. Schlecht

Otorhinolaryngology - Head & Neck Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. Methods: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes. Results: Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study. Conclusions: Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.

Original language	English (US)
Article number	200237
Journal	Tumour Virus Research
Volume	13
DOIs	https://doi.org/10.1016/j.tvr.2022.200237
State	Published - Jun 2022

Keywords

HPV
HPV clearance
HPV prevalence
Human immunodeficiency virus
Human papillomavirus
Incidence
Oral cavity

ASJC Scopus subject areas

Infectious Diseases
Virology
Cancer Research
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tvr.2022.200237

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Riddell, J., Brouwer, A. F., Walline, H. M., Campredon, L. P., Meza, R., Eisenberg, M. C., Andrus, E. C., Delinger, R. L., Yost, M. L., McCloskey, J. K., Thomas, T. B., Huang, S., Ferris, R. L., Shin, D. M., Fakhry, C., Ow, T., Li, D., Berlot, A., Carey, T. E., & Schlecht, N. F. (2022). Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults. Tumour Virus Research, 13, [200237]. https://doi.org/10.1016/j.tvr.2022.200237

Riddell, J, Brouwer, AF, Walline, HM, Campredon, LP, Meza, R, Eisenberg, MC, Andrus, EC, Delinger, RL, Yost, ML, McCloskey, JK, Thomas, TB, Huang, S, Ferris, RL, Shin, DM, Fakhry, C, Ow, T, Li, D, Berlot, A, Carey, TE & Schlecht, NF 2022, 'Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults', Tumour Virus Research, vol. 13, 200237. https://doi.org/10.1016/j.tvr.2022.200237

@article{c275eb6c34da40cf961e9fb877007466,

title = "Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults",

abstract = "Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. Methods: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes. Results: Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study. Conclusions: Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.",

keywords = "HPV, HPV clearance, HPV prevalence, Human immunodeficiency virus, Human papillomavirus, Incidence, Oral cavity",

author = "James Riddell and Brouwer, {Andrew F.} and Walline, {Heather M.} and Campredon, {Lora P.} and Rafael Meza and Eisenberg, {Marisa C.} and Andrus, {Emily C.} and Delinger, {Rachel L.} and Yost, {Monica L.} and McCloskey, {Jodi K.} and Thomas, {Trey B.} and Suiyuan Huang and Ferris, {Robert L.} and Shin, {Dong Moon} and Carole Fakhry and Thomas Ow and Daniel Li and Ashley Berlot and Carey, {Thomas E.} and Schlecht, {Nicolas F.}",

note = "Funding Information: This work was supported by the NIH NCI JHU SPORE CA P50 supplement: Oral HPV infection and clearance in HIV infected and non-infected individuals, National Institutes for Health Grant U01CA182915 , NIH NCI U01 PAR-13-081: From mechanism to population: Modeling HPV-related oropharyngeal Carcinogenesis, the University of Michigan M-Cubed Program, a pilot grant from the University of Michigan Comprehensive Cancer Center's Cancer Epidemiology & Prevention Program (supported by the National Cancer Institute of the National Institutes of Health grant P30CA046592 ), and the Michigan Institute for Clinical and Health Research (NIH Grant UL1TR000433 ). This project was also supported in part by National Cancer Institute P30 grants to the Einstein Cancer Research Center ( CA013330 ), Roswell Park Comprehensive Cancer Center ( CA016056 ). Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = jun,

doi = "10.1016/j.tvr.2022.200237",

language = "English (US)",

volume = "13",

journal = "Tumour Virus Research",

issn = "2666-6790",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

AU - Riddell, James

AU - Brouwer, Andrew F.

AU - Walline, Heather M.

AU - Campredon, Lora P.

AU - Meza, Rafael

AU - Eisenberg, Marisa C.

AU - Andrus, Emily C.

AU - Delinger, Rachel L.

AU - Yost, Monica L.

AU - McCloskey, Jodi K.

AU - Thomas, Trey B.

AU - Huang, Suiyuan

AU - Ferris, Robert L.

AU - Shin, Dong Moon

AU - Fakhry, Carole

AU - Ow, Thomas

AU - Li, Daniel

AU - Berlot, Ashley

AU - Carey, Thomas E.

AU - Schlecht, Nicolas F.

N1 - Funding Information: This work was supported by the NIH NCI JHU SPORE CA P50 supplement: Oral HPV infection and clearance in HIV infected and non-infected individuals, National Institutes for Health Grant U01CA182915 , NIH NCI U01 PAR-13-081: From mechanism to population: Modeling HPV-related oropharyngeal Carcinogenesis, the University of Michigan M-Cubed Program, a pilot grant from the University of Michigan Comprehensive Cancer Center's Cancer Epidemiology & Prevention Program (supported by the National Cancer Institute of the National Institutes of Health grant P30CA046592 ), and the Michigan Institute for Clinical and Health Research (NIH Grant UL1TR000433 ). This project was also supported in part by National Cancer Institute P30 grants to the Einstein Cancer Research Center ( CA013330 ), Roswell Park Comprehensive Cancer Center ( CA016056 ). Publisher Copyright: © 2022 The Author(s)

PY - 2022/6

Y1 - 2022/6

N2 - Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. Methods: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes. Results: Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study. Conclusions: Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.

AB - Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls. Methods: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes. Results: Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study. Conclusions: Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.

KW - HPV

KW - HPV clearance

KW - HPV prevalence

KW - Human immunodeficiency virus

KW - Human papillomavirus

KW - Incidence

KW - Oral cavity

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UR - http://www.scopus.com/inward/citedby.url?scp=85129890420&partnerID=8YFLogxK

U2 - 10.1016/j.tvr.2022.200237

DO - 10.1016/j.tvr.2022.200237

M3 - Article

C2 - 35460939

AN - SCOPUS:85129890420

SN - 2666-6790

VL - 13

JO - Tumour Virus Research

JF - Tumour Virus Research

M1 - 200237

ER -

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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