TY - JOUR
T1 - Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups
AU - Kowalski, Timothy J.
AU - Houpt, Thomas A.
AU - Jahng, Jeongwon
AU - Okada, Nori
AU - Chua, Streamson C.
AU - Smith, Gerard P.
PY - 1998
Y1 - 1998
N2 - Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ hybridization. PreproNPY expression within the arcuate nucleus was localized to cells in the medial portion. Twenty-four hours of food, water, and maternal deprivation significantly increased the relative abundance of preproNPY mRNA in pups on postnatal day (P) 2, P9, P12, and P15 by 14-31%. This response, however, was not observed on P5. The absence of an effect on P5 and the magnitude of the response at the other ages tested were not correlated with the amount of weight lost during deprivation.
AB - Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ hybridization. PreproNPY expression within the arcuate nucleus was localized to cells in the medial portion. Twenty-four hours of food, water, and maternal deprivation significantly increased the relative abundance of preproNPY mRNA in pups on postnatal day (P) 2, P9, P12, and P15 by 14-31%. This response, however, was not observed on P5. The absence of an effect on P5 and the magnitude of the response at the other ages tested were not correlated with the amount of weight lost during deprivation.
KW - Arcuate nucleus
KW - In situ hybridization
KW - Neonate
KW - Starvation
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U2 - 10.1152/ajpregu.1998.275.2.r466
DO - 10.1152/ajpregu.1998.275.2.r466
M3 - Article
C2 - 9688681
AN - SCOPUS:0031844514
SN - 0363-6119
VL - 275
SP - R466-R470
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 2 44-2
ER -