TY - JOUR
T1 - On the theory of tumor self-seeding
T2 - Implications for metastasis progression in humans
AU - Aguirre-Ghiso, Julio A.
N1 - Funding Information:
The author would like to thank colleagues and members of the laboratory for helpful discussions. JAA-G is supported by grants from the Samuel Waxman Cancer Research Foundation Tumor Dormancy Program, the National Cancer Institute (CA109182), the NIEHS (ES017146) and NYSTEM-ESSCB.
PY - 2010/4/28
Y1 - 2010/4/28
N2 - Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.
AB - Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.
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U2 - 10.1186/bcr2561
DO - 10.1186/bcr2561
M3 - Article
C2 - 20459594
AN - SCOPUS:77956626993
SN - 1465-5411
VL - 12
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 2
M1 - 304
ER -
