Omega-3 fatty acids coordinate glucose and lipid metabolism in diabetic patients

Pasquale Mone, Fahimeh Varzideh, Urna Kansakar, Carmine Infante, Angela Lombardi, Antonio de Donato, Salvatore Frullone, Gaetano Santulli

Research output: Contribution to journalComment/debatepeer-review

11 Scopus citations


Omega 3 polyunsaturated fatty acids (n-3 PUFA) are known to have beneficial effects on cardiovascular and metabolic health. However, whether different sources of n-3 PUFA, for instance fatty fish vs vegetable oils, could elicit different effects on glucose and lipid metabolism, remains to be determined. Herein we examine recent findings showing that while a plant-based n-3 PUFA supplementation for six months can reduce fasting blood glucose, marine-based n-3 PUFA can instead reduce serum levels of triglycerides. We also discuss the potential molecular mechanisms that could underlie these different effects on the regulation of glycolipid metabolism.

Original languageEnglish (US)
Article number31
JournalLipids in Health and Disease
Issue number1
StatePublished - Dec 2022


  • Fish oil
  • Omega-3 fatty acids
  • PUFA
  • T2DM
  • Vegetable oils

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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