TY - JOUR
T1 - Objectively Measured Sedentary Behavior, Physical Activity, and Cardiometabolic Risk in Hispanic Youth
T2 - Hispanic Community Health Study/Study of Latino Youth
AU - Strizich, Garrett
AU - Kaplan, Robert C.
AU - Sotres-Alvarez, Daniela
AU - Diaz, Keith M.
AU - Daigre, Amber L.
AU - Carnethon, Mercedes R.
AU - Vidot, Denise C.
AU - Delamater, Alan M.
AU - Perez, Lilian
AU - Perreira, Krista
AU - Isasi, Carmen R.
AU - Qi, Qibin
N1 - Funding Information:
Financial Support: The Hispanic Community Health Study/ Study of Latino Youth was supported by the National Heart, Lung, and Blood Institute (NHLBI; Grant R01HL102130 to C.R.I.). Youth participants are drawn from the Hispanic Community Health Study/Study of Latinos, which was supported by contracts from the NHLBI to the University of North Carolina (Grant N01-HC65233), University of Miami (Grant N01-HC65234), Albert Einstein College of Medicine (Grant N01-HC65235), Northwestern University (Grant N01-HC65236), and San Diego State University (Grant N01-HC65237). The following contribute to this study through a transfer of funds to NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurologic Disorders and Stroke, and the Office of Dietary Supplements. Additional support was provided by the Life Course Methodology Core of the New York Regional Center for Diabetes Translation Research (Grant DK111022-8786 to C.R.I.). Q.Q. is supported by a Scientist Development Award (Award K01HL129892) from the NHLBI.
Publisher Copyright:
© 2018 Endocrine Society.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Context: Time spent in moderate-to-vigorous physical activity (MVPA), but not in sedentary behavior (SB), is related to cardiometabolic risk among non-Hispanic white youth. Objective: Examine associations of SB and MVPA with cardiometabolic risk factors among Hispanic/ Latino youth. Design: Cross-sectional analysis. Setting: Four US communities. Participants: Hispanic/Latino youth (N = 1,426) ages 8 to 16 years. Measurements: Associations of MVPA and SB, measured using 7-day accelerometer data (independent variables), with markers of glucose and lipid metabolism, inflammation, and endothelial function (dependent variables), were assessed in multivariable linear regression models while adjusting for sociodemographic characteristics and accelerometer wear time. Additional models controlled for obesity measures. Results: SB comprised a mean (SD) of 75% (13%) of accelerometer wear time; mean (SD) time of MVPA was 35 min/d (22 min/d). Deleterious levels of high-density lipoproteincholesterol (HDLC), triglycerides, insulin resistance, C-reactive protein, and plasminogen activator inhibitor-1 were associated with lower levels of MVPA and higher levels of SB (all P < 0.05). Associations of MVPA with log-transformed triglyceride concentrations (b per 15-min/d increment, 20.039; SE, 0.018; P = 0.037) and SB with HDL-C (b per 30-min/d increment, 20.63; SE, 0.26; P = 0.018), but not those with other markers, remained significant after adjusting for MVPA or SB and further adjustment for body mass index and waist circumference. Higher SB tertiles were associated with lower soluble receptor for advanced glycation end products in fully adjusted models (P for trend = 0.037). Conclusions: Physiological precursors of diabetes and cardiovascular disease were associated with MVPA and SB among US Hispanic/Latino youth, a group that bears a disproportionate burden of metabolic disorders.
AB - Context: Time spent in moderate-to-vigorous physical activity (MVPA), but not in sedentary behavior (SB), is related to cardiometabolic risk among non-Hispanic white youth. Objective: Examine associations of SB and MVPA with cardiometabolic risk factors among Hispanic/ Latino youth. Design: Cross-sectional analysis. Setting: Four US communities. Participants: Hispanic/Latino youth (N = 1,426) ages 8 to 16 years. Measurements: Associations of MVPA and SB, measured using 7-day accelerometer data (independent variables), with markers of glucose and lipid metabolism, inflammation, and endothelial function (dependent variables), were assessed in multivariable linear regression models while adjusting for sociodemographic characteristics and accelerometer wear time. Additional models controlled for obesity measures. Results: SB comprised a mean (SD) of 75% (13%) of accelerometer wear time; mean (SD) time of MVPA was 35 min/d (22 min/d). Deleterious levels of high-density lipoproteincholesterol (HDLC), triglycerides, insulin resistance, C-reactive protein, and plasminogen activator inhibitor-1 were associated with lower levels of MVPA and higher levels of SB (all P < 0.05). Associations of MVPA with log-transformed triglyceride concentrations (b per 15-min/d increment, 20.039; SE, 0.018; P = 0.037) and SB with HDL-C (b per 30-min/d increment, 20.63; SE, 0.26; P = 0.018), but not those with other markers, remained significant after adjusting for MVPA or SB and further adjustment for body mass index and waist circumference. Higher SB tertiles were associated with lower soluble receptor for advanced glycation end products in fully adjusted models (P for trend = 0.037). Conclusions: Physiological precursors of diabetes and cardiovascular disease were associated with MVPA and SB among US Hispanic/Latino youth, a group that bears a disproportionate burden of metabolic disorders.
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U2 - 10.1210/jc.2018-00356
DO - 10.1210/jc.2018-00356
M3 - Article
C2 - 29947786
AN - SCOPUS:85054127984
SN - 0021-972X
VL - 103
SP - 3289
EP - 3298
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -
