Objective response of multiple myeloma to cyclosporin a

Peter H. Wiernik; Janice P. Dutcher; Andrea N. Leaf; Zenghua Liao; Elisabeth Paietta; David L. Rosenstreich

doi:10.3109/10428199409114154

Objective response of multiple myeloma to cyclosporin a

Peter H. Wiernik, Janice P. Dutcher, Andrea N. Leaf, Zenghua Liao, Elisabeth Paietta, David L. Rosenstreich

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.

Original language	English (US)
Pages (from-to)	167-170
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	16
Issue number	1-2
DOIs	https://doi.org/10.3109/10428199409114154
State	Published - 1994

Keywords

Cyclosporin therapy
Myeloma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/10428199409114154

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title = "Objective response of multiple myeloma to cyclosporin a",

abstract = "Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.",

keywords = "Cyclosporin therapy, Myeloma",

author = "Wiernik, {Peter H.} and Dutcher, {Janice P.} and Leaf, {Andrea N.} and Zenghua Liao and Elisabeth Paietta and Rosenstreich, {David L.}",

note = "Funding Information: Supported in part by Cancer Center Core Grant P30CA13330 awarded by the National Cancer Institute.",

year = "1994",

doi = "10.3109/10428199409114154",

language = "English (US)",

volume = "16",

pages = "167--170",

journal = "Leukemia and Lymphoma",

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T1 - Objective response of multiple myeloma to cyclosporin a

AU - Wiernik, Peter H.

AU - Dutcher, Janice P.

AU - Leaf, Andrea N.

AU - Liao, Zenghua

AU - Paietta, Elisabeth

AU - Rosenstreich, David L.

N1 - Funding Information: Supported in part by Cancer Center Core Grant P30CA13330 awarded by the National Cancer Institute.

PY - 1994

Y1 - 1994

N2 - Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.

AB - Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A, one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.

KW - Cyclosporin therapy

KW - Myeloma

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ER -

Objective response of multiple myeloma to cyclosporin a

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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