TY - JOUR
T1 - Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines
AU - Coutinho, Hannah M.
AU - McGarvey, Stephen T.
AU - Acosta, Luz P.
AU - Manalo, Daria L.
AU - Langdon, Gretchen C.
AU - Leenstra, Tjalling
AU - Kanzaria, Hemal K.
AU - Solomon, Julie
AU - Wu, Haiwei
AU - Olveda, Remigio M.
AU - Kurtis, Jonathan D.
AU - Friedman, Jennifer F.
N1 - Funding Information:
Received 8 November 2004; accepted 11 February 2005; electronically published 30 June 2005. Financial support: National Institutes of Health (grants RO1AI48123 and K23AI52125). Potential conflicts of interest: none reported. a Current affiliations: University of California School of Medicine, San Francisco (H.K.K.); Department of Anthropology and School of Medicine, Emory University, Atlanta, Georgia (J.S.). Reprints or correspondence: Dr. Hannah M. Coutinho, Brown University, International Health Institute, Box G/B 426, Providence, RI 02912 (hannah_coutinho@ brown.edu).
PY - 2005/8/1
Y1 - 2005/8/1
N2 - In a cross-sectional study of 641 Schistosoma japonicum-infected individuals in Leyte, Philippines, who were 7-30 years old, we determined the grade of hepatic fibrosis (HF) by ultrasound and used anthropometric measurements and hemoglobin levels to assess nutritional status. Serum levels of interleukin (IL)-1, IL-6, and IL-10; tumor-necrosis factor (TNF)-α; soluble TNF-α receptor I; and C-reactive protein (CRP) were measured to examine the association between these markers of inflammation and HF grade. HF was present in 8.9% of the cohort; the majority of cases were mild (grade I), and severe (grade II or grade III) cases occurred only in male individuals. Compared with individuals without HF, those with severe HF-and, to a lesser degree, those with mild HF-had a significantly lower body-mass index (BMI) and BMI z-score, a higher prevalence of anemia, and a higher level of CRP and were more likely to produce IL-6; furthermore, those with severe HF had a significantly higher level of IL-1, compared with those either without HF or with mild HF. These findings suggest that even mild HF is associated with nutritional morbidity and underscore the importance of early recognition and treatment. In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia.
AB - In a cross-sectional study of 641 Schistosoma japonicum-infected individuals in Leyte, Philippines, who were 7-30 years old, we determined the grade of hepatic fibrosis (HF) by ultrasound and used anthropometric measurements and hemoglobin levels to assess nutritional status. Serum levels of interleukin (IL)-1, IL-6, and IL-10; tumor-necrosis factor (TNF)-α; soluble TNF-α receptor I; and C-reactive protein (CRP) were measured to examine the association between these markers of inflammation and HF grade. HF was present in 8.9% of the cohort; the majority of cases were mild (grade I), and severe (grade II or grade III) cases occurred only in male individuals. Compared with individuals without HF, those with severe HF-and, to a lesser degree, those with mild HF-had a significantly lower body-mass index (BMI) and BMI z-score, a higher prevalence of anemia, and a higher level of CRP and were more likely to produce IL-6; furthermore, those with severe HF had a significantly higher level of IL-1, compared with those either without HF or with mild HF. These findings suggest that even mild HF is associated with nutritional morbidity and underscore the importance of early recognition and treatment. In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia.
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U2 - 10.1086/430929
DO - 10.1086/430929
M3 - Article
C2 - 15995969
AN - SCOPUS:22544438408
SN - 0022-1899
VL - 192
SP - 528
EP - 536
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -