Nuclear bridges within multinucleated giant cells in subacute encephalitis of acquired immune deficiency syndrome (AIDS)

Six cases of subacute encephalitis in AIDS were examined with special reference to the nuclear morphology of multinucleated giant cells (MGC's). Although rare in some, all cases showed nuclear bridges which were thin strands connecting individual nuclei. Even more frequently observed were nuclear processes which were probably parts of nuclear bridges or disconnected ends of nuclear bridges. Nuclear bridges and processes were not features of mitosis but were composed of nucleoplasm. They appear to be a feature of MGC's in AIDS but may not be limited to this condition.