TY - JOUR
T1 - Nrf2 a molecular therapeutic target for Astaxanthin
AU - Kohandel, Zeynab
AU - Farkhondeh, Tahereh
AU - Aschner, Michael
AU - Samarghandian, Saeed
N1 - Publisher Copyright:
© 2021
PY - 2021/5
Y1 - 2021/5
N2 - Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic and muscloprotective effects of ATX.
AB - Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic and muscloprotective effects of ATX.
KW - Astaxanthin
KW - Inflammation
KW - Nrf2
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85100877491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100877491&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2021.111374
DO - 10.1016/j.biopha.2021.111374
M3 - Review article
C2 - 33761600
AN - SCOPUS:85100877491
SN - 0753-3322
VL - 137
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 111374
ER -
