Nrf2 a molecular therapeutic target for Astaxanthin

Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic and anti-proliferative properties. In the present review, we discuss the role of Nrf2 in mediating the anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic and muscloprotective effects of ATX.

Original languageEnglish (US)
Article number111374
JournalBiomedicine and Pharmacotherapy
StatePublished - May 2021


  • Astaxanthin
  • Inflammation
  • Nrf2
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology


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