TY - JOUR
T1 - Norovirus disease among older adults
AU - Tsai, Helen
AU - Yune, Philip
AU - Rao, Mana
N1 - Funding Information:
This research was supported in part by the National Science Foundation (Grant #SOC77-27365), the Graduate Student Program Development Fund at the University of Arizona, and the National Institute of Mental Health (Grant #PHS G 5132 MH14598).
Publisher Copyright:
© The Author(s), 2022.
PY - 2022
Y1 - 2022
N2 - Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development.
AB - Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development.
KW - norovirus
KW - older adults
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U2 - 10.1177/20499361221136760
DO - 10.1177/20499361221136760
M3 - Review article
AN - SCOPUS:85141946528
SN - 2049-9361
VL - 9
JO - Therapeutic Advances in Infectious Disease
JF - Therapeutic Advances in Infectious Disease
ER -
