Nonthrombogenic Roles of the Left Atrial Appendage: JACC Review Topic of the Week

Mohamad Alkhouli, Luigi Di Biase, Andrea Natale, Charanjit S. Rihal, David R. Holmes, Samuel Asirvatham, Krzysztof Bartus, Dhanunjaya Lakkireddy, Paul A. Friedman

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The atrial appendage (LAA) is a well-established source of cardioembolism in patients with atrial fibrillation. Therefore, research involving the LAA has largely focused on its thrombogenic attribute and the utility of its exclusion in stroke prevention. However, recent studies have highlighted several novel functions of the LAA that may have important therapeutic implications. In this paper, we provide a concise overview of the LAA anatomy and summarize the emerging data on its nonthrombogenic roles.

Original languageEnglish (US)
Pages (from-to)1063-1075
Number of pages13
JournalJournal of the American College of Cardiology
Volume81
Issue number11
DOIs
StatePublished - Mar 21 2023

Keywords

  • atrial fibrillation
  • hemodynamics
  • left atrial appendage
  • progenitor cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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