TY - JOUR
T1 - Nonalcoholic Fatty Liver Disease and Mean Platelet Volume
T2 - A Systemic Review and Meta-analysis
AU - Madan, Shivank A.
AU - John, Febin
AU - Pitchumoni, Capecomorin S.
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Nonalcoholic fatty liver disease (NAFLD) is linked to obesity, metabolic syndrome, and cardiovascular disease. Increased mean platelet volume (MPV), a marker of platelet activity, is associated with acute myocardial infarction, stroke, thrombosis, and increased mortality after myocardial infarction. The purpose of this study was to perform a meta-analysis to investigate the relationship between NAFLD and MPV. Methodology: A systematic search of MEDLINE (Ovid), PubMed, and CINAHL databases from 1950 to May 2014, complemented with manual review of references of published articles for studies comparing MPV in patients with and without NAFLD was done. Results were pooled using both fixed and random effects model. Results: Our analysis from pooling of data from 8 observational studies including 1428 subjects (NAFLD=842 and non-NAFLD=586) showed that MPV was significantly higher in patients with NAFLD than those without. The standardized mean difference in MPV between NAFLD and controls was 0.457 (95% confidence interval: 0.348-0.565, P 0.001) using fixed and 0.612 (95% confidence interval: 0.286-0.938, P 0.001) using random effects model. Conclusions: This study suggests that MPV is significantly higher in patients with NAFLD, indicating the presence of increased platelet activity in such patients. Future research is needed to investigate whether this increased MPV is associated with increased cardiovascular disease in patients with NAFLD.
AB - Nonalcoholic fatty liver disease (NAFLD) is linked to obesity, metabolic syndrome, and cardiovascular disease. Increased mean platelet volume (MPV), a marker of platelet activity, is associated with acute myocardial infarction, stroke, thrombosis, and increased mortality after myocardial infarction. The purpose of this study was to perform a meta-analysis to investigate the relationship between NAFLD and MPV. Methodology: A systematic search of MEDLINE (Ovid), PubMed, and CINAHL databases from 1950 to May 2014, complemented with manual review of references of published articles for studies comparing MPV in patients with and without NAFLD was done. Results were pooled using both fixed and random effects model. Results: Our analysis from pooling of data from 8 observational studies including 1428 subjects (NAFLD=842 and non-NAFLD=586) showed that MPV was significantly higher in patients with NAFLD than those without. The standardized mean difference in MPV between NAFLD and controls was 0.457 (95% confidence interval: 0.348-0.565, P 0.001) using fixed and 0.612 (95% confidence interval: 0.286-0.938, P 0.001) using random effects model. Conclusions: This study suggests that MPV is significantly higher in patients with NAFLD, indicating the presence of increased platelet activity in such patients. Future research is needed to investigate whether this increased MPV is associated with increased cardiovascular disease in patients with NAFLD.
KW - MPV
KW - NAFLD
KW - Nonalcoholic fatty liver disease
KW - mean platelet volume
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U2 - 10.1097/MCG.0000000000000340
DO - 10.1097/MCG.0000000000000340
M3 - Review article
C2 - 25984978
AN - SCOPUS:84951742606
SN - 0192-0790
VL - 50
SP - 69
EP - 74
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - 1
ER -