Non-uraemic calciphylaxis (NUC) postliver transplantation

Simona Frunza-Stefan, Silpa Poola-Kella, Kristi Silver

Research output: Contribution to journalArticlepeer-review


Calciphylaxis is a rare and life-threatening disease characterized by cutaneous arteriolar stenosis and vascular thrombosis leading to skin ischaemia and necrosis. While calciphylaxis occurs mostly in patients with end-stage renal disease, the disorder has been described in patients with normal renal function, namely non-uraemic calciphylaxis (NUC). A 41-year-old African-American woman presented with a painful ulcerative rash on her thighs and right buttock 2 months after undergoing an orthotopic liver transplantation. She underwent debridement of the lesions and an excisional biopsy of one of the lesions, which revealed calciphylaxis. She was treated with sodium thiosulfate, cinacalcet and hyperbaric oxygen with complete resolution of the lesions 4-5 months after presentation. While she was treated with a course of high-dose glucocorticoids after the transplant, she did not have other risk factors for calciphylaxis. NUC should be considered in the differential diagnosis of necrotic skin lesions in postliver transplant patients.

Original languageEnglish (US)
Article number226537
JournalBMJ case reports
StatePublished - 2018
Externally publishedYes


  • dermatology
  • liver disease

ASJC Scopus subject areas

  • Medicine(all)


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