Non-invasive assessment of low risk acute chest pain in the emergency department: A comparative meta-analysis of prospective studies

Jorge Romero, S. Arman Husain, Anthony A. Holmes, Iosif Kelesidis, Patricia Chavez, M. Khalid Mojadidi, Jeffrey M. Levsky, Omar Wever-Pinzon, Cynthia Taub, Harikrishna Makani, Mark I. Travin, Ileana L. Piña, Mario J. Garcia

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: The aim of this meta-analysis was to compare the diagnostic accuracy of cardiac computed tomographic angiography (CCTA), stress echocardiography (SE) and radionuclide single photon emission computed tomography (SPECT) for the assessment of chest pain in emergency department (ED) setting. Methods: A systematic review of Medline, Cochrane and Embase was undertaken for prospective clinical studies assessing the diagnostic efficacy of CCTA, SE or SPECT, as compared to intracoronary angiography (ICA) or the later presence of major adverse clinical outcomes (MACE), in patients presenting to the ED with chest pain. Standard approach and bivariate analysis were performed. Results: Thirty-seven studies (15 CCTA, 9 SE, 13 SPECT) comprising a total of 7800 patients fulfilled inclusion criteria. The respectiveweightedmean sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and total diagnostic accuracy for CCTA were: 95%, 99%, 84%, 100% and 99%, for SE were: 84%, 94%, 73%, 96% and 96%, and for SPECT were: 85%, 86%, 57%, 95% and 88%. There was no significant difference between modalities in terms of NPV. Bivariate analysis revealed that CCTA had statistically greater sensitivity, specificity, PPV and overall diagnostic accuracy when compared to SE and SPECT. Conclusions: All three modalities, when employed by an experienced clinician, are highly accurate. Each has its own strengths and limitations making each well suited for different patient groups. CCTA has higher accuracy than SE and SPECT, but it has many drawbacks, most importantly its lack of physiologic data.

Original languageEnglish (US)
Pages (from-to)565-580
Number of pages16
JournalInternational Journal of Cardiology
Issue number1
StatePublished - May 6 2015


  • Coronary computed tomographic angiography
  • Meta-analysis
  • Non-invasive chest pain assessment
  • Single-photon emission computed tomography
  • Stress echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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