Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

Mehrdad Valizadeh; Ehsan Derafsh; Fahimeh Abdi Abyaneh; Sayedeh Kiana Parsamatin; Fatemeh Zahra Rashidi Noshabad; Azam Alinaghipour; Zahra Yaghoobi; Abdolkarim Talebi Taheri; Ehsan Dadgostar; Michael Aschner; Hamed Mirzaei; Omid Reza Tamtaji; Fatemeh Nabavizadeh

doi:10.1007/s12035-023-03849-z

Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

Mehrdad Valizadeh
, Ehsan Derafsh
, Fahimeh Abdi Abyaneh
, Sayedeh Kiana Parsamatin
, Fatemeh Zahra Rashidi Noshabad
, Azam Alinaghipour
, Zahra Yaghoobi
, Abdolkarim Talebi Taheri
, Ehsan Dadgostar
, Michael Aschner
, Hamed Mirzaei
, Omid Reza Tamtaji
, Fatemeh Nabavizadeh

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis.

Original language	English (US)
Pages (from-to)	4508-4537
Number of pages	30
Journal	Molecular Neurobiology
Volume	61
Issue number	7
DOIs	https://doi.org/10.1007/s12035-023-03849-z
State	Published - Jul 2024

Keywords

Apoptosis
Circular RNA
Long non-coding RNA
MicroRNA
Neurodegenerative disorders

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Neurology
Cellular and Molecular Neuroscience

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10.1007/s12035-023-03849-z

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Valizadeh, M., Derafsh, E., Abdi Abyaneh, F., Parsamatin, S. K., Noshabad, F. Z. R., Alinaghipour, A., Yaghoobi, Z., Taheri, A. T., Dadgostar, E., Aschner, M., Mirzaei, H., Tamtaji, O. R., & Nabavizadeh, F. (2024). Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis. Molecular Neurobiology, 61(7), 4508-4537. https://doi.org/10.1007/s12035-023-03849-z

Valizadeh, M, Derafsh, E, Abdi Abyaneh, F, Parsamatin, SK, Noshabad, FZR, Alinaghipour, A, Yaghoobi, Z, Taheri, AT, Dadgostar, E, Aschner, M, Mirzaei, H, Tamtaji, OR & Nabavizadeh, F 2024, 'Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis', Molecular Neurobiology, vol. 61, no. 7, pp. 4508-4537. https://doi.org/10.1007/s12035-023-03849-z

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abstract = "Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis.",

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author = "Mehrdad Valizadeh and Ehsan Derafsh and \{Abdi Abyaneh\}, Fahimeh and Parsamatin, \{Sayedeh Kiana\} and Noshabad, \{Fatemeh Zahra Rashidi\} and Azam Alinaghipour and Zahra Yaghoobi and Taheri, \{Abdolkarim Talebi\} and Ehsan Dadgostar and Michael Aschner and Hamed Mirzaei and Tamtaji, \{Omid Reza\} and Fatemeh Nabavizadeh",

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doi = "10.1007/s12035-023-03849-z",

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AU - Valizadeh, Mehrdad

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AU - Parsamatin, Sayedeh Kiana

AU - Noshabad, Fatemeh Zahra Rashidi

AU - Alinaghipour, Azam

AU - Yaghoobi, Zahra

AU - Taheri, Abdolkarim Talebi

AU - Dadgostar, Ehsan

AU - Aschner, Michael

AU - Mirzaei, Hamed

AU - Tamtaji, Omid Reza

AU - Nabavizadeh, Fatemeh

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.

PY - 2024/7

Y1 - 2024/7

N2 - Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and tissue damage may become apparent. Recently, the scientific studies of the non-coding RNAs (ncRNAs) has provided new information of the molecular mechanisms that contribute to neurodegenerative disorders. Numerous reports have documented that ncRNAs have important contributions to several biological processes associated with the increase of neurodegenerative disorders. In addition, microRNAs (miRNAs), circular RNAs (circRNAs), as well as, long ncRNAs (lncRNAs) represent ncRNAs subtypes with the usual dysregulation in neurodegenerative disorders. Dysregulating ncRNAs has been associated with inhibiting or stimulating apoptosis in neurodegenerative disorders. Therefore, this review highlighted several ncRNAs linked to apoptosis in neurodegenerative disorders. CircRNAs, lncRNAs, and miRNAs were also illustrated completely regarding the respective signaling pathways of apoptosis.

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Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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