Nitric oxide treatment for pulmonary hypertension after neonatal cardiac operation

Aamir S. Shah, Arthur J. Smerling, Jan M. Quaegebeur, Robert E. Michler

Research output: Contribution to journalArticlepeer-review


This report describes a newborn with transposition of the great arteries who underwent a Blalock-Taussig shunt with transient improvement in oxygenation, but required emergent insertion of a central shunt later the same day due to progressive hypoxia and cardiac arrest. Two hours after central shunt insertion, sudden episodes of hypoxia and hypotension developed that were resistant to all pharmocologic therapy. Inhaled nitric oxide (25 ppm) was then administered with dramatic improvement in oxygenation and hemodynamics within minutes. The patient's condition stabilized after these measures, and nitric oxide therapy was discontinued after 2 days.

Original languageEnglish (US)
Pages (from-to)1791-1793
Number of pages3
JournalThe Annals of Thoracic Surgery
Issue number6
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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