TY - JOUR
T1 - Nfatc1 directs the endocardial progenitor cells to make heart valve primordium
AU - Wu, Bingruo
AU - Baldwin, H. Scott
AU - Zhou, Bin
N1 - Funding Information:
B.Z. is supported by funds from the National Institutes of Health (NIH) and American Heart Association (AHA) (National Scientist Development Award). H.S.B. is supported by funds from the NIH and AHA (National Established Investigator Award).
PY - 2013/11
Y1 - 2013/11
N2 - Heart valves arise from the cardiac endocardial cushions located at the atrioventricular canal (AVC) and cardiac outflow tract (OFT) during development. A subpopulation of cushion endocardial cells undergoes endocardial to mesenchymal transformation (EMT) and generates the cushion mesenchyme, which is then remodeled into the interstitial tissue of the mature valves. The cushion endocardial cells that do not undertake EMT proliferate to elongate valve leaflets. During EMT and the post-EMT valve remodeling, endocardial cells at the cushions highly express nuclear factor in activated T cell, cytoplasmic 1 (Nfatc1), a transcription factor required for valve formation in mice. In this review, we present the current knowledge of Nfatc1 roles in the ontogeny of heart valves with a focus on the fate decision of the endocardial cells in the processes of EMT and valve remodeling.
AB - Heart valves arise from the cardiac endocardial cushions located at the atrioventricular canal (AVC) and cardiac outflow tract (OFT) during development. A subpopulation of cushion endocardial cells undergoes endocardial to mesenchymal transformation (EMT) and generates the cushion mesenchyme, which is then remodeled into the interstitial tissue of the mature valves. The cushion endocardial cells that do not undertake EMT proliferate to elongate valve leaflets. During EMT and the post-EMT valve remodeling, endocardial cells at the cushions highly express nuclear factor in activated T cell, cytoplasmic 1 (Nfatc1), a transcription factor required for valve formation in mice. In this review, we present the current knowledge of Nfatc1 roles in the ontogeny of heart valves with a focus on the fate decision of the endocardial cells in the processes of EMT and valve remodeling.
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U2 - 10.1016/j.tcm.2013.04.003
DO - 10.1016/j.tcm.2013.04.003
M3 - Review article
C2 - 23669445
AN - SCOPUS:84884819690
SN - 1050-1738
VL - 23
SP - 294
EP - 300
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 8
ER -