NF-κB dysregulation in multiple myeloma

Geoffrey M. Matthews, Ricardo de Matos Simoes, Eugen Dhimolea, Michal Sheffer, Sara Gandolfi, Olga Dashevsky, Jeffrey D. Sorrell, Constantine S. Mitsiades

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


The nuclear factor-κB (NF-κB) transcription factor family plays critical roles in the pathophysiology of hematologic neoplasias, including multiple myeloma. The current review examines the roles that this transcription factor system plays in multiple myeloma cells and the nonmalignant accessory cells of the local microenvironment; as well as the evidence indicating that a large proportion of myeloma patients harbor genomic lesions which perturb diverse genes regulating the activity of NF-κB. This article also discusses the therapeutic targeting of the NF-κB pathway using proteasome inhibitors, a pharmacological class that has become a cornerstone in the therapeutic management of myeloma; and reviews some of the future challenges and opportunities for NF-κB-related research in myeloma.

Original languageEnglish (US)
Pages (from-to)68-76
Number of pages9
JournalSeminars in Cancer Biology
StatePublished - Aug 1 2016
Externally publishedYes


  • Microenvironment
  • Myeloma
  • NF-kappaB
  • Proteasome inhibitors
  • Stromal cells

ASJC Scopus subject areas

  • Cancer Research


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