New twists in the AXL(e) of tumor progression

Balazs Halmos; Eric B. Haura

doi:10.1126/scisignal.aai7619

New twists in the AXL(e) of tumor progression

Balazs Halmos
, Eric B. Haura

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Patients with a mesenchymal subtype of ovarian cancer face a poor prognosis with limited treatment options to halt metastatic progression. In this issue of Science Signaling, Antony et al. found that the kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells. AXL inhibitors may thus slow tumor progression in this subset of patients.

Original language	English (US)
Article number	fs14
Journal	Science Signaling
Volume	9
Issue number	448
DOIs	https://doi.org/10.1126/scisignal.aai7619
State	Published - Oct 4 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.aai7619

Cite this

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title = "New twists in the AXL(e) of tumor progression",

abstract = "Patients with a mesenchymal subtype of ovarian cancer face a poor prognosis with limited treatment options to halt metastatic progression. In this issue of Science Signaling, Antony et al. found that the kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells. AXL inhibitors may thus slow tumor progression in this subset of patients.",

author = "Balazs Halmos and Haura, \{Eric B.\}",

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AU - Haura, Eric B.

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PY - 2016/10/4

Y1 - 2016/10/4

N2 - Patients with a mesenchymal subtype of ovarian cancer face a poor prognosis with limited treatment options to halt metastatic progression. In this issue of Science Signaling, Antony et al. found that the kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells. AXL inhibitors may thus slow tumor progression in this subset of patients.

AB - Patients with a mesenchymal subtype of ovarian cancer face a poor prognosis with limited treatment options to halt metastatic progression. In this issue of Science Signaling, Antony et al. found that the kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells. AXL inhibitors may thus slow tumor progression in this subset of patients.

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UR - https://www.scopus.com/pages/publications/84990210511#tab=citedBy

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DO - 10.1126/scisignal.aai7619

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JO - Science Signaling

JF - Science Signaling

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M1 - fs14

ER -

New twists in the AXL(e) of tumor progression

Abstract

UN SDGs

ASJC Scopus subject areas

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