@article{deb634b014b14bc680e22681eff9f93d,
title = "Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder",
abstract = "Background: Atypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood. Methods: We sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6–17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132). Results: Statistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain. Conclusions: These results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism.",
keywords = "Adaptive behavior, Auditory processing, Autism Spectrum Disorder, Electroencephalography, Event related potentials, Lateralization",
author = "Mairin Cotter and Seydanur Reisli and Francisco, {Ana Alves} and Wakim, {Kathryn Mary} and Leona Oakes and Crosse, {Michael J.} and Foxe, {John J.} and Sophie Molholm",
note = "Funding Information: Primary funding for this work was provided through a grant from the U.S. National Institute of Mental Health (MH085322 to S.M. and J.J.F.). The Human Clinical Phenotyping Core, where the majority of the children enrolled in this study were clinically evaluated, is a facility of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (IDDRC) which is funded through a center grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD P30 HD071593; U54 HD090260; P50 HD105352). Dr. Wakim received support from a NICHD sponsored fellowship (T32 HDO98067). Work on ASD at the University of Rochester (UR) collaborating site is funded by a center grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD P50 HD103536) supporting the UR Intellectual and Developmental Disabilities Research Center (UR-IDDRC). Funding Information: We extend our deep appreciation to all of the families that have generously given their time to participate in this research. This work could not be done without the clinicians that have performed or supervised clinical and cognitive testing including: Alice Brandwein; Juliana Bates; Hilary Gomes, and Natalie Russo. We are grateful to the research assistants and technicians that have put in great efforts to collect high quality EEG data while ensuring the comfort of our participants, including: Douwe Horsthuis, Alaina Berruti, Frantzy Acluche, Greg Peters, Sarah Ruberman, and Elise Taverna. An earlier version of this manuscript was submitted to the Department of Psychology at Fordham University towards fulfillment of the first author{\textquoteright}s master{\textquoteright}s degree. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1186/s11689-023-09480-2",
language = "English (US)",
volume = "15",
journal = "Journal of Neurodevelopmental Disorders",
issn = "1866-1947",
publisher = "Springer New York",
number = "1",
}