TY - JOUR
T1 - Neurophysiological investigation of spontaneous correlated and anticorrelated fluctuations of the BOLD signal
AU - Keller, Corey J.
AU - Bickel, Stephan
AU - Honey, Christopher J.
AU - Groppe, David M.
AU - Entz, Laszlo
AU - Craddock, R. Cameron
AU - Lado, Fred A.
AU - Kelly, Clare
AU - Milham, Michael
AU - Mehta, Ashesh D.
PY - 2013/4/10
Y1 - 2013/4/10
N2 - Analyses of intrinsic fMRI BOLD signal fluctuations reliably reveal correlated and anticorrelated functional networks in the brain. Because the BOLD signal is an indirect measure of neuronal activity and anticorrelations can be introduced by preprocessing steps, such as global signal regression, the neurophysiological significance of correlated and anticorrelated BOLD fluctuations is a source of debate. Here, we address this question by examining the correspondence between the spatial organization of correlated BOLD fluctuations and correlated fluctuations in electrophysiological high y power signals recorded directly from the cortical surface of 5 patients. We demonstrate that both positive and negative BOLD correlations have neurophysiological correlates reflected in fluctuations of spontaneous neuronal activity. Although applying global signal regression to BOLD signals results in some BOLD anticorrelations that are not apparent in the ECoG data, it enhances the neuronal-hemodynamic correspondence overall. Together, these findings provide support for the neurophysiological fidelity of BOLD correlations and anticorrelations.
AB - Analyses of intrinsic fMRI BOLD signal fluctuations reliably reveal correlated and anticorrelated functional networks in the brain. Because the BOLD signal is an indirect measure of neuronal activity and anticorrelations can be introduced by preprocessing steps, such as global signal regression, the neurophysiological significance of correlated and anticorrelated BOLD fluctuations is a source of debate. Here, we address this question by examining the correspondence between the spatial organization of correlated BOLD fluctuations and correlated fluctuations in electrophysiological high y power signals recorded directly from the cortical surface of 5 patients. We demonstrate that both positive and negative BOLD correlations have neurophysiological correlates reflected in fluctuations of spontaneous neuronal activity. Although applying global signal regression to BOLD signals results in some BOLD anticorrelations that are not apparent in the ECoG data, it enhances the neuronal-hemodynamic correspondence overall. Together, these findings provide support for the neurophysiological fidelity of BOLD correlations and anticorrelations.
UR - http://www.scopus.com/inward/record.url?scp=84875986911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875986911&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.4837-12.2013
DO - 10.1523/JNEUROSCI.4837-12.2013
M3 - Article
C2 - 23575832
AN - SCOPUS:84875986911
SN - 0270-6474
VL - 33
SP - 6333
EP - 6342
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 15
ER -