@article{cca8d5c560c74673ac20896a6a7bb7ee,
title = "Neuronal Cell Cycle Events Link Caloric Intake to Obesity",
abstract = "Obesity is a neurological disorder that operates by favoring energy storage within adipose depots and increased caloric intake. Most cases of human obesity are acquired without any underlying genetic basis. Here, we suggest that obesity can impair the function of some hypothalamic neurons critical to body weight regulation. Genetic ablation of the retinoblastoma (Rb) gene within pro-opiomelanocortin (POMC) neurons leads to death of the neurons and subsequent obesity. The Rb protein (pRb), a key inhibitor of the cell cycle, can also be inactivated by cyclin dependent kinase (CDK)-mediated phosphorylation. Extensive development led to the production of FDA-approved CDK4/6 inhibitors. Based on our own results, we propose that maintaining or re-instating pRb function using CDK4/6 inhibitors are potentially effective treatments of diet-induced obesity (DIO).",
keywords = "cell cycle, diet-induced obesity, hypothalamus",
author = "Niloy Iqbal and Zhu, {LIang I.} and Chua, {Streamson C.}",
note = "Funding Information: This work was funded by National Institutes of Health (NIH) grant 5 R01 DK111043 to S.C. and L.Z. and F30 DK116532 to N.J.I. Imaging analysis was supported by the Einstein Analytical Imaging Facility, National Cancer Institute (NCI) Cancer Center Support grant P30CA013330. Additional support and resources were provided by Einstein Sinai Diabetes Research Center Grant P60DK020541, the New York Obesity Research Center Grant 1P01DK026687, and Liver Pathobiology and Gene Therapy Research Core Center Grant 5P30-DK041296. Funding Information: This work was funded by National Institutes of Health ( NIH ) grant 5 R01 DK111043 to S.C. and L.Z., and F30 DK116532 to N.J.I. Imaging analysis was supported by the Einstein Analytical Imaging Facility, National Cancer Institute ( NCI ) Cancer Center Support grant P30CA013330. Additional support and resources were provided by Einstein Sinai Diabetes Research Center Grant P60DK020541, the New York Obesity Research Center Grant 1P01DK026687, and Liver Pathobiology and Gene Therapy Research Core Center Grant 5P30-DK041296. Publisher Copyright: {\textcopyright} 2019",
year = "2020",
month = jan,
doi = "10.1016/j.tem.2019.09.001",
language = "English (US)",
volume = "31",
pages = "46--52",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "1",
}
