Neuroinflammation in the pathogenesis of early life epileptic encephalopathies

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.

Original languageEnglish (US)
Title of host publicationAcute Encephalopathy and Encephalitis in Infancy and Its Related Disorders
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780323530903
ISBN (Print)9780323530880
StatePublished - 2018


  • ACTH
  • Cognition
  • Cytokines
  • Dysplasia
  • Infantile spasms
  • Interleukin
  • MTOR
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)


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