Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia

Raghavan Sheelakumari, Cheminnikara Bineesh, Tinu Varghese, Chandrasekharan Kesavadas, Joe Verghese, Pavagada S. Mathuranath

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Neuroanatomical correlates of apathy and disinhibition, behavioral abnormalities in behavioral variant Frontotemporal dementia (bvFTD) remain unclear. In this study 45 participants (25 bvFTD patients and 20 controls) provided data on clinical, neuropsychological, behavioral (on Frontal Systems Behavior (FrSBe) Scale), cortical volume (on voxel-based morphometry (VBM)) and tract based spatial fractional anisotropy ((FA) on magnetic resonance imaging (MRI), allowing examination of the neural correlates of apathy and disinhibition. The patients with bvFTD had predominant grey matter loss and corresponding white matter fractional anisotropy reduction in the frontal and temporal lobe compared to the controls. Grey matter loss in frontal, temporal and limbic structures correlated with apathy and degeneration in temporal limbic brain areas correlated with disinhibition. FA changes in inferior fronto-occipital fasciculus and forceps minor correlated with apathy and fibre integrity changes in the superior longitudinal fasciculus correlated with disinhibition. The current study suggests that apathy and disinhibition arises due to changes in the frontal, temporal and limbic brain areas in bvFTD.

Original languageEnglish (US)
Pages (from-to)2004-2011
Number of pages8
JournalBrain Imaging and Behavior
Issue number5
StatePublished - Oct 1 2020


  • Behavioral variant FTD
  • Fractional anisotropy
  • Frontal system Behavioral scale
  • Inferior fronto-occipital fasciculus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Radiology Nuclear Medicine and imaging
  • Behavioral Neuroscience


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