Nerves in cancer

Ali H. Zahalka; Paul S. Frenette

doi:10.1038/s41568-019-0237-2

Nerves in cancer

Ali H. Zahalka, Paul S. Frenette

Medicine

Research output: Contribution to journal › Review article › peer-review

212 Scopus citations

Abstract

The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

Original language	English (US)
Pages (from-to)	143-157
Number of pages	15
Journal	Nature Reviews Cancer
Volume	20
Issue number	3
DOIs	https://doi.org/10.1038/s41568-019-0237-2
State	Published - Mar 1 2020

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41568-019-0237-2

Cite this

@article{65ed1073a8cf436daa77c1b922ad5f00,

title = "Nerves in cancer",

abstract = "The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.",

author = "Zahalka, {Ali H.} and Frenette, {Paul S.}",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Nature Limited.",

year = "2020",

month = mar,

day = "1",

doi = "10.1038/s41568-019-0237-2",

language = "English (US)",

volume = "20",

pages = "143--157",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Nerves in cancer

AU - Zahalka, Ali H.

AU - Frenette, Paul S.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

AB - The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

UR - http://www.scopus.com/inward/record.url?scp=85078341480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078341480&partnerID=8YFLogxK

U2 - 10.1038/s41568-019-0237-2

DO - 10.1038/s41568-019-0237-2

M3 - Review article

C2 - 31974491

AN - SCOPUS:85078341480

SN - 1474-175X

VL - 20

SP - 143

EP - 157

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 3

ER -

Nerves in cancer

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this