Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases

Pari Sohrabi; Zafer Habip; Suat Saribas; Asli Vatan; Harika Oyku Dinc; Yagiz M. Altun; Tevhide Ziver; Reyhan Caliskan; Mehmet Demirci; Omer Uysal; Pelin Yuksel; Bekir Kocazeybek

doi:10.2217/fvl-2017-0005

Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases

Pari Sohrabi, Zafer Habip, Suat Saribas, Asli Vatan, Harika Oyku Dinc, Yagiz M. Altun, Tevhide Ziver, Reyhan Caliskan, Mehmet Demirci, Omer Uysal, Pelin Yuksel, Bekir Kocazeybek

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.

Original language	English (US)
Pages (from-to)	409-419
Number of pages	11
Journal	Future Virology
Volume	12
Issue number	8
DOIs	https://doi.org/10.2217/fvl-2017-0005
State	Published - Aug 2017
Externally published	Yes

Keywords

HBV
isolated anti-HBc (aHBc-only)
neopterin
sCD14

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fvl-2017-0005

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@article{43ddfab3eb5e491b8c150f4238268534,

title = "Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases",

abstract = "Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.",

keywords = "HBV, isolated anti-HBc (aHBc-only), neopterin, sCD14",

author = "Pari Sohrabi and Zafer Habip and Suat Saribas and Asli Vatan and Dinc, {Harika Oyku} and Altun, {Yagiz M.} and Tevhide Ziver and Reyhan Caliskan and Mehmet Demirci and Omer Uysal and Pelin Yuksel and Bekir Kocazeybek",

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year = "2017",

month = aug,

doi = "10.2217/fvl-2017-0005",

language = "English (US)",

volume = "12",

pages = "409--419",

journal = "Future Virology",

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TY - JOUR

T1 - Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases

AU - Sohrabi, Pari

AU - Habip, Zafer

AU - Saribas, Suat

AU - Vatan, Asli

AU - Dinc, Harika Oyku

AU - Altun, Yagiz M.

AU - Ziver, Tevhide

AU - Caliskan, Reyhan

AU - Demirci, Mehmet

AU - Uysal, Omer

AU - Yuksel, Pelin

AU - Kocazeybek, Bekir

PY - 2017/8

Y1 - 2017/8

N2 - Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.

AB - Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern.

KW - HBV

KW - isolated anti-HBc (aHBc-only)

KW - neopterin

KW - sCD14

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Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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