Neonatal seizures: Advances in diagnosis and management

Elissa G. Yozawitz; Ronit M. Pressler; Eli M. Mizrahi

doi:10.1002/epi4.70090

Neonatal seizures: Advances in diagnosis and management

Elissa G. Yozawitz
, Ronit M. Pressler
, Eli M. Mizrahi

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of neonatal seizures. Plain Language Summary: Neonatal seizures, occurring within the first 4 weeks of life, present unique challenges due to the immature neonatal brain. The International League Against Epilepsy (ILAE) Neonatal Task Force revolutionized diagnosis and management through classification, syndrome definition, and treatment guidelines. Despite advancements, challenges persist, including accurate diagnosis and limited evidence-based treatment protocols, emphasizing the need for global efforts to standardize care.

Original language	English (US)
Journal	Epilepsia Open
DOIs	https://doi.org/10.1002/epi4.70090
State	Accepted/In press - 2025

Keywords

EEG semiology
classification
epilepsy
neonatal seizures

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/epi4.70090

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title = "Neonatal seizures: Advances in diagnosis and management",

abstract = "The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of neonatal seizures. Plain Language Summary: Neonatal seizures, occurring within the first 4 weeks of life, present unique challenges due to the immature neonatal brain. The International League Against Epilepsy (ILAE) Neonatal Task Force revolutionized diagnosis and management through classification, syndrome definition, and treatment guidelines. Despite advancements, challenges persist, including accurate diagnosis and limited evidence-based treatment protocols, emphasizing the need for global efforts to standardize care.",

keywords = "EEG semiology, classification, epilepsy, neonatal seizures",

author = "Yozawitz, \{Elissa G.\} and Pressler, \{Ronit M.\} and Mizrahi, \{Eli M.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.",

year = "2025",

doi = "10.1002/epi4.70090",

language = "English (US)",

journal = "Epilepsia Open",

issn = "2470-9239",

publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Neonatal seizures

T2 - Advances in diagnosis and management

AU - Yozawitz, Elissa G.

AU - Pressler, Ronit M.

AU - Mizrahi, Eli M.

PY - 2025

Y1 - 2025

N2 - The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of neonatal seizures. Plain Language Summary: Neonatal seizures, occurring within the first 4 weeks of life, present unique challenges due to the immature neonatal brain. The International League Against Epilepsy (ILAE) Neonatal Task Force revolutionized diagnosis and management through classification, syndrome definition, and treatment guidelines. Despite advancements, challenges persist, including accurate diagnosis and limited evidence-based treatment protocols, emphasizing the need for global efforts to standardize care.

AB - The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of neonatal seizures. Plain Language Summary: Neonatal seizures, occurring within the first 4 weeks of life, present unique challenges due to the immature neonatal brain. The International League Against Epilepsy (ILAE) Neonatal Task Force revolutionized diagnosis and management through classification, syndrome definition, and treatment guidelines. Despite advancements, challenges persist, including accurate diagnosis and limited evidence-based treatment protocols, emphasizing the need for global efforts to standardize care.

KW - EEG semiology

KW - classification

KW - epilepsy

KW - neonatal seizures

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U2 - 10.1002/epi4.70090

DO - 10.1002/epi4.70090

M3 - Article

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SN - 2470-9239

JO - Epilepsia Open

JF - Epilepsia Open

ER -

Neonatal seizures: Advances in diagnosis and management

Abstract

Keywords

ASJC Scopus subject areas

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