Natural history of established low grade cervical intraepithelial (CIN 1) lesions

Nisha Bansal, Jason D. Wright, Carmel J. Cohen, Thomas J. Herzog

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The aim of the present study was to ascertain the natural history of cervical intraepithelial lesions 1 (CIN 1) and to develop recommendations to optimize follow-up. Patients and Methods: Patients referred for colposcopy from January, 1996 to July, 2005 were reviewed. A prospectively maintained database was quarried for demographic, clinical, and pathologic data. Results: The cohort included 1,001 patients with CIN 1. At 6 months, 330 patients (49%) regressed to normal, 305 (45%) had persistent low grade, while 45 (7%) progressed to high grade lesions. At 12 months, of those with negative pathology at 6 months, 200 (80%) remained negative, 42 (16%) demonstrated low grade and 9 (4%) progressed to high grade lesions. Of those with low grade lesions at 6 months, 131 (50%) regressed, 121 (46%) had persistent low grade, and 10 (4%) progressed to high grade lesions. Conclusion: Our data demonstrates a low rate of progression for CIN 1, suggesting it may be reasonable to prolong the screening interval in women with CIN 1.

Original languageEnglish (US)
Pages (from-to)1763-1766
Number of pages4
JournalAnticancer Research
Issue number3 B
StatePublished - May 2008
Externally publishedYes


  • Cervical dysplasia
  • Cervical intraepithelial neoplasia
  • Colposcopy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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