Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review

Bradley S. Galer; Richard B. Lipton; Seymour Solomon; Lawrence C. Newman; Egilius L.H. Spierings

doi:10.1111/j.1526-4610.1991.hed3107446.x

Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review

Bradley S. Galer, Richard B. Lipton, Seymour Solomon, Lawrence C. Newman, Egilius L.H. Spierings

Neurology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

SYNOPSIS Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31‐year‐old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

Original language	English (US)
Pages (from-to)	446-450
Number of pages	5
Journal	Headache: The Journal of Head and Face Pain
Volume	31
Issue number	7
DOIs	https://doi.org/10.1111/j.1526-4610.1991.hed3107446.x
State	Published - Jul 1991

Keywords

coronary
ergotamine
methysergide
vasoconstriction

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1526-4610.1991.hed3107446.x

Cite this

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title = "Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review",

abstract = "SYNOPSIS Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31‐year‐old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.",

keywords = "coronary, ergotamine, methysergide, vasoconstriction",

author = "Galer, {Bradley S.} and Lipton, {Richard B.} and Seymour Solomon and Newman, {Lawrence C.} and Spierings, {Egilius L.H.}",

year = "1991",

month = jul,

doi = "10.1111/j.1526-4610.1991.hed3107446.x",

language = "English (US)",

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T1 - Myocardial Ischemia Related to Ergot Alkaloids

T2 - A Case Report and Literature Review

AU - Galer, Bradley S.

AU - Lipton, Richard B.

AU - Solomon, Seymour

AU - Newman, Lawrence C.

AU - Spierings, Egilius L.H.

PY - 1991/7

Y1 - 1991/7

N2 - SYNOPSIS Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31‐year‐old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

AB - SYNOPSIS Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31‐year‐old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

KW - coronary

KW - ergotamine

KW - methysergide

KW - vasoconstriction

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JO - Headache: The Journal of Head and Face Pain

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Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

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