Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar; Yuxin Dong; Robert S. Holzman; John Belisle; Irene S. Kourbeti; Tsering Sherpa; Rany Condos; William N. Rom; Suman Laal

doi:10.1128/CVI.00158-06

Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar
, Yuxin Dong
, Robert S. Holzman
, John Belisle
, Irene S. Kourbeti
, Tsering Sherpa
, Rany Condos
, William N. Rom
, Suman Laal

Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Original language	English (US)
Pages (from-to)	1291-1293
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1128/CVI.00158-06
State	Published - Nov 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00158-06

Cite this

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title = "Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis",

abstract = "The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from \textasciitilde{}80\% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.",

author = "Achkar, \{Jacqueline M.\} and Yuxin Dong and Holzman, \{Robert S.\} and John Belisle and Kourbeti, \{Irene S.\} and Tsering Sherpa and Rany Condos and Rom, \{William N.\} and Suman Laal",

year = "2006",

month = nov,

doi = "10.1128/CVI.00158-06",

language = "English (US)",

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pages = "1291--1293",

journal = "Clinical and Vaccine Immunology",

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T1 - Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

AU - Achkar, Jacqueline M.

AU - Dong, Yuxin

AU - Holzman, Robert S.

AU - Belisle, John

AU - Kourbeti, Irene S.

AU - Sherpa, Tsering

AU - Condos, Rany

AU - Rom, William N.

AU - Laal, Suman

PY - 2006/11

Y1 - 2006/11

N2 - The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

AB - The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

UR - https://www.scopus.com/pages/publications/34248644000

UR - https://www.scopus.com/pages/publications/34248644000#tab=citedBy

U2 - 10.1128/CVI.00158-06

DO - 10.1128/CVI.00158-06

M3 - Article

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AN - SCOPUS:34248644000

SN - 1556-6811

VL - 13

SP - 1291

EP - 1293

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 11

ER -

Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Abstract

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