Multivariate survival data under bivariate frailty: An estimating equation approach

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A modified frailty model is developed to improve the computing efficiency of the bivariate frailty model proposed by Xue and Brookmeyer (1996, Lifetime Data Analysis 2, 277-290) for the analysis of multivariate survival data. Originally, the frailty was modeled parametrically and a modified EM approach was used to estimate the parameters of interest, however, with intensive computations. The modified frailty model formulates a Poisson regression model and applies quasi-likelihood estimating equations to estimate the parameters of interest. This procedure not only significantly reduces the computation but also avoids using a parametric assumption for the frailty distribution. Simulation studies show the estimators perform well. The method is also applied to a mental health care dataset.

Original languageEnglish (US)
Pages (from-to)1631-1637
Number of pages7
Issue number4
StatePublished - 1998
Externally publishedYes


  • Heterogeneity
  • Poisson formulation
  • Quasi-likelihood

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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