Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: A concise route to access chromans

Chamini V. Karunaratne; Ryan G. Sarkisian; Jennifer Reeves; Yongming Deng; Kraig A. Wheeler; Hong Wang

doi:10.1039/c7ob00753a

Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: A concise route to access chromans

Chamini V. Karunaratne, Ryan G. Sarkisian, Jennifer Reeves, Yongming Deng, Kraig A. Wheeler, Hong Wang

Biochemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine-metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

Original language	English (US)
Pages (from-to)	4933-4936
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	23
DOIs	https://doi.org/10.1039/c7ob00753a
State	Published - 2017

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c7ob00753a

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Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: A concise route to access chromans. / Karunaratne, Chamini V.; Sarkisian, Ryan G.; Reeves, Jennifer et al.
In: Organic and Biomolecular Chemistry, Vol. 15, No. 23, 2017, p. 4933-4936.

Research output: Contribution to journal › Article › peer-review

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AU - Reeves, Jennifer

AU - Deng, Yongming

AU - Wheeler, Kraig A.

AU - Wang, Hong

PY - 2017

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AB - An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine-metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

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Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: A concise route to access chromans

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