TY - JOUR
T1 - Motoric Cognitive Risk Syndrome
T2 - Prevalence and Risk Factors in Japanese Seniors
AU - Doi, Takehiko
AU - Verghese, Joe
AU - Shimada, Hiroyuki
AU - Makizako, Hyuma
AU - Tsutsumimoto, Kota
AU - Hotta, Ryo
AU - Nakakubo, Sho
AU - Suzuki, Takao
N1 - Publisher Copyright:
© 2015 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Objectives: Motoric cognitive syndrome (MCR), a newly described predementia syndrome characterized by cognitive complaints and slow gait, is associated with increased risk of developing dementia. Due to the potential differences in health, behavioral, and lifestyle factors between races that can influence dementia risk, it is important to examine risk factors for MCR in different countries. This study aimed to report the prevalence as well as modifiable factors associated with MCR in Japanese community-dwelling older adults. Design: A cross-sectional design. Setting: General community. Participants: A total of 9683 older adults (52% women, mean age: 73.6 years) participating in the National Center for Geriatrics and Gerontology Study of Geriatric Syndromes. Measurements: Participants were screened for presence of MCR at baseline. The association of selected modifiable risk factors (medical illness, depressive symptoms, and falls) and lifestyle variables (obesity, physical inactivity, smoking, and alcohol consumption) with MCR was examined using multivariate logistic regression analysis. Results: At cross-section, 619 participants met criteria for MCR, with an overall prevalence 6.4% (95% CI 5.9-6.9). A higher prevalence of MCR was seen with advancing age (P < .001), but there were no sex differences. Diabetes (adjusted odds ratio [OR] 1.47, P = .001), depressive symptoms (OR 3.57, P < .001), and falls (OR 1.45, P < .001) were associated with increased risk of MCR. Among the lifestyle factors, obesity (OR 1.26, P = .018) and physical inactivity (OR 1.57, P < .001) were associated with increased risk of MCR. Conclusion: MCR is common in the elderly Japanese population. The potentially modifiable risk and lifestyle factors identified for MCR should be further studied to develop interventions.
AB - Objectives: Motoric cognitive syndrome (MCR), a newly described predementia syndrome characterized by cognitive complaints and slow gait, is associated with increased risk of developing dementia. Due to the potential differences in health, behavioral, and lifestyle factors between races that can influence dementia risk, it is important to examine risk factors for MCR in different countries. This study aimed to report the prevalence as well as modifiable factors associated with MCR in Japanese community-dwelling older adults. Design: A cross-sectional design. Setting: General community. Participants: A total of 9683 older adults (52% women, mean age: 73.6 years) participating in the National Center for Geriatrics and Gerontology Study of Geriatric Syndromes. Measurements: Participants were screened for presence of MCR at baseline. The association of selected modifiable risk factors (medical illness, depressive symptoms, and falls) and lifestyle variables (obesity, physical inactivity, smoking, and alcohol consumption) with MCR was examined using multivariate logistic regression analysis. Results: At cross-section, 619 participants met criteria for MCR, with an overall prevalence 6.4% (95% CI 5.9-6.9). A higher prevalence of MCR was seen with advancing age (P < .001), but there were no sex differences. Diabetes (adjusted odds ratio [OR] 1.47, P = .001), depressive symptoms (OR 3.57, P < .001), and falls (OR 1.45, P < .001) were associated with increased risk of MCR. Among the lifestyle factors, obesity (OR 1.26, P = .018) and physical inactivity (OR 1.57, P < .001) were associated with increased risk of MCR. Conclusion: MCR is common in the elderly Japanese population. The potentially modifiable risk and lifestyle factors identified for MCR should be further studied to develop interventions.
KW - Cognition
KW - Dementia
KW - Gait
KW - Lifestyle
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U2 - 10.1016/j.jamda.2015.09.003
DO - 10.1016/j.jamda.2015.09.003
M3 - Article
C2 - 26476498
AN - SCOPUS:84947781612
SN - 1525-8610
VL - 16
SP - 1103.e21-1103.e25
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 12
ER -