Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

Devin T. Corrigan; Elise Ishida; Delphi Chatterjee; Todd L. Lowary; Jacqueline M. Achkar

doi:10.1016/j.tim.2022.07.001

Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

Devin T. Corrigan
, Elise Ishida
, Delphi Chatterjee
, Todd L. Lowary
, Jacqueline M. Achkar

Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

Original language	English (US)
Pages (from-to)	22-35
Number of pages	14
Journal	Trends in Microbiology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.tim.2022.07.001
State	Published - Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antigen–antibody interactions
biomarker
glycans
lipoglycans
mycobacteria
oligosaccharides
point-of-care tests

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

Access to Document

10.1016/j.tim.2022.07.001

Cite this

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title = "Monoclonal antibodies to lipoarabinomannan/arabinomannan {\textendash} characteristics and implications for tuberculosis research and diagnostics",

abstract = "Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.",

keywords = "antigen{\textendash}antibody interactions, biomarker, glycans, lipoglycans, mycobacteria, oligosaccharides, point-of-care tests",

author = "Corrigan, \{Devin T.\} and Elise Ishida and Delphi Chatterjee and Lowary, \{Todd L.\} and Achkar, \{Jacqueline M.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2023",

month = jan,

doi = "10.1016/j.tim.2022.07.001",

language = "English (US)",

volume = "31",

pages = "22--35",

journal = "Trends in Microbiology",

issn = "0966-842X",

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TY - JOUR

T1 - Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

AU - Corrigan, Devin T.

AU - Ishida, Elise

AU - Chatterjee, Delphi

AU - Lowary, Todd L.

AU - Achkar, Jacqueline M.

PY - 2023/1

Y1 - 2023/1

N2 - Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

AB - Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

KW - antigen–antibody interactions

KW - biomarker

KW - glycans

KW - lipoglycans

KW - mycobacteria

KW - oligosaccharides

KW - point-of-care tests

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UR - https://www.scopus.com/pages/publications/85135177104#tab=citedBy

U2 - 10.1016/j.tim.2022.07.001

DO - 10.1016/j.tim.2022.07.001

M3 - Review article

C2 - 35918247

AN - SCOPUS:85135177104

SN - 0966-842X

VL - 31

SP - 22

EP - 35

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 1

ER -

Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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