Abstract
Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF- R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.
Original language | English (US) |
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Pages (from-to) | 140-145 |
Number of pages | 6 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology