Molecular mechanisms of nonmuscle myosin-II regulation

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318 Scopus citations


Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Cell Biology


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