Molecular mechanism of mutant CALR–Mediated transformation

Robert F. Stanley, Ulrich Steidl

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)–driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments, and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant CALR C-terminal domain and the thrombopoietin receptor MPL.

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalCancer discovery
Issue number4
StatePublished - Apr 2016

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Molecular mechanism of mutant CALR–Mediated transformation'. Together they form a unique fingerprint.

Cite this