Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update

Lei Zhang; Martin H. Bluth; Amarpreet Bhalla

doi:10.1016/j.cll.2018.03.003

Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update

Lei Zhang
, Martin H. Bluth
, Amarpreet Bhalla

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.

Original language	English (US)
Title of host publication	Clinics in Laboratory Medicine
Editors	Louis Mansur, Bernard Riemer, David McClintock
Publisher	W.B. Saunders
Pages	367-384
Number of pages	18
Volume	38
Edition	2
ISBN (Print)	9780323610728
DOIs	https://doi.org/10.1016/j.cll.2018.03.003
State	Published - Jun 2018
Externally published	Yes

Keywords

Cell free nucleic acid
Cholangiocarcinoma
Hepatic adenoma
Hepatocellular carcinoma
Liver
Molecular diagnostics
Pancreatic neoplasms

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cll.2018.03.003

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Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update. / Zhang, Lei; Bluth, Martin H.; Bhalla, Amarpreet.
Clinics in Laboratory Medicine. ed. / Louis Mansur; Bernard Riemer; David McClintock. Vol. 38 2. ed. W.B. Saunders, 2018. p. 367-384.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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title = "Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update",

abstract = "Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.",

keywords = "Cell free nucleic acid, Cholangiocarcinoma, Hepatic adenoma, Hepatocellular carcinoma, Liver, Molecular diagnostics, Pancreatic neoplasms",

author = "Lei Zhang and Bluth, \{Martin H.\} and Amarpreet Bhalla",

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year = "2018",

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AU - Bhalla, Amarpreet

PY - 2018/6

Y1 - 2018/6

N2 - Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.

AB - Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and choangiocarcinoma display heterogeneity at both morphologic and molecular levels Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.

KW - Cell free nucleic acid

KW - Cholangiocarcinoma

KW - Hepatic adenoma

KW - Hepatocellular carcinoma

KW - Liver

KW - Molecular diagnostics

KW - Pancreatic neoplasms

UR - https://www.scopus.com/pages/publications/85047018701

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U2 - 10.1016/j.cll.2018.03.003

DO - 10.1016/j.cll.2018.03.003

M3 - Chapter

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AN - SCOPUS:85047018701

SN - 9780323610728

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BT - Clinics in Laboratory Medicine

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PB - W.B. Saunders

ER -

Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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